Endocrine Abstracts

Background: Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a very common electrolyte disorder in older patients leading often to hospital admissions. Symptoms can vary between mild disabilities (e.g. nausea, dizziness, attention deficits, gait disturbance) to severe life-threatening conditions (e.g. seizures, coma). Treatment of SIADH is challenging in particular when fluid restriction is limited or even not effective in restoring n...

Introduction: Hyperinsulinaemic hypoglycemia after gastric bypass surgery is a rare but probably underestimated complication. The mechanisms leading to hypoglycemia are complex and incompletely understood and involve several factors: A part from decreasing insulin resistance, caloric restriction and alteration of nutrient delivery, enhanced secretion of insulin and incretins (GLP1 and GIP), altered physiology of other hormones and dysregulation of counterregulatory effectors s...

Introduction: Leydig cell tumors (LCT) are rare testicular tumors, characterized by mostly benign etiology. Due to their secretory activity androgen- and/or estrogen-excess can occur.Case report: A 42-year old patient with recent history of cerebrovascular incident was admitted to the hematology department for diagnostic work-up of new-onset erythrocytosis (hemoglobin 185 g/l [reference 127–163], hematocrit 0.53 [0.37–0.46]). Myeloproliferati...

Background: Medical therapy with dopamine agonists (DA) is the primary treatment in most patients with prolactinomas. ‘Classical’ surgical indications are mainly intolerance of DA therapy or non-responders. Focusing on a possible shift of recent indications towards a surgical approach, we retrospectively analyzed the long-term results of surgical treatment and compared them to the medically treated female patients with prolactinomas.Patients an...

Background: In contrast to females with prolactinoma, male patients usually present with a history of long-standing hypogonadism and a macroadenoma on MRI-scan. Data is scarce about the effect of hypogonadism on bone health in these patients. We, therefore, investigated retrospectively the cohort of male patients with prolactinoma at our institution.Patients and methods: Between 1983 and 2007, the chards of 44 male patients with prolactinoma were reviewe...

Background: Surgically treated patients with NFA often present with secondary hypogonadism. Hypogonadism is a well known risk factor for osteopenia or osteoporosis. The aim of this study was to assess (a) the frequency of osteopenia/osteoporosis in a single centre Swiss cohort of patients with operated NFA and (b) whether gender or hypogonadism impacts on bone density at follow up.Methods: Data of patients with NFAs diagnosed between 1967 and 2005 were a...

Purpose: We aim at prospectively comparing the detection rate of glucagon-like peptide 1 receptor (GLP1R) PET/CT vs GLP1R SPECT/CT vs standardised contrast enhanced 3T MRI in patients with endogenous hyperinsulinaemic hypoglycaemia.Methods: 14 patients with neuroglycopenic symptoms due to endogenous hyperinsulinaemic hypoglycaemia were already enrolled (mean age 56 years, ten females and four males). A standardized contrast enhanced 3T MRI was performed....

Background: Patients with type 2 diabetes and overweight have a chronic activation of the innate immune system possibly explaining the increased risk of a hyperinflammatory response and severe COVID-19. We aimed to test whether blockade of interleukin-1β(IL-1β) using canakinumab improves clinical outcome.Methods: CanCovDia was a multicenter, randomised, double-blind, placebo-controlled trial to assess the efficacy of canakinumab plus standard-o...